The FTSE100 fell in early trading as concerns over EU debt problems offset any reassurance the market might take from easing oil prices.
Falling after a small gain the previous session, the FTSE100 dropped 29 points to 5,940.65 at just after 9.30am.
Jittery traders were awaiting news from Europe of the results of a Portuguese bond auction, slated for later today.
Prudential was leading in early trading following strong full year results for 2010. Its share price rose 3.5% to 739p per share.
It was a mixed bag in European markets, with the German Dax up 0.19% to 7,178.12 points but the French Cac 40 falling 0.19% to 4,008.26 points.
Overnight in the US, financial companies pushed shares higher on signs banks may soon raise their dividends. Financial stocks in the S&P index rose 2.2%.
Airline stocks were also up as oil price pressures decreased after OPEC discussed whether to increase production.
The Dow Jones index ended the day up 124 points, or 1%, at 12,214 points.
Japanese shares were extending gains for a second day on Wednesday after a pullback in oil prices. By the midday break, the benchmark Nikkei rose 1% to 10,633.46.
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